| Bioactivity | αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1]. |
| Target | IC50: 12 nM (rat α9α10), 52 nM (human α9α10), 520 nM (mouse α1β1δε), 660 nM (rat α7), 940 nM (rat α3β2), 1380 nM (rat α6/α3β4), 1610 nM (rat α2β2), 6930 nM (rat α3β4) |
| Name | αO-Conotoxin GeXIVA |
| CAS | 2010167-25-4 |
| Sequence | Thr-Cys-Arg-Ser-Ser-Gly-Arg-Tyr-Cys-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Cys-Arg-Arg-Ile-Thr-Asp-Ala-Cys-Val (Disulfide bridge:Cys2-Cys9;Cys20-Cys27) |
| Shortening | TCRSSGRYCRSPYDRRRRYCRRITDACV (Disulfide bridge:Cys2-Cys9;Cys20-Cys27) |
| Formula | C139H227N55O41S4 |
| Molar Mass | 3452.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu P, et al. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J Med Chem. 2020 Feb 27;63(4):1564-1575. |
αO-Conotoxin GeXIVA
CAS: 2010167-25-4 F: C139H227N55O41S4 W: 3452.89
αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIV
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