| Bioactivity | α-Conotoxin LtIA is an α3β2 nAChR blocker (IC50=9.8 nM), that can be obtained from Conus litteratus venom. Alpha-Conotoxin LtIA can be used in the study of neurological diseases (such as Parkinson's disease, pain)[1]. |
| Target | IC50: 9.8 nM (α3β2 nAChR) |
| Name | α-Conotoxin LtIA |
| Sequence | Gly-Cys-Cys-Ala-Arg-Ala-Ala-Cys-Ala-Gly-Ile-His-Gln-Glu-Leu-Cys-NH2 (Disulfide bridge:Cys2-Cys8, Cys3-Cys16) |
| Shortening | GCCARAACAGIHQELC-NH2 (Disulfide bridge:Cys2-Cys8, Cys3-Cys16) |
| Formula | C62H101N23O19S4 |
| Molar Mass | 1600.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo S, et al. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J Biol Chem. 2010 Apr 16;285(16):12355-66. |