| Bioactivity | sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1]. |
| Target | IC50: 0.4 nM (hsEH), 1.94 ± 0.67 nM (hAChE), 615 ± 34 nM (hBChE), 4.3 nM (msEH), 2.61 ± 0.16 nM (mAChE) |
| Name | sEH/AChE-IN-3 |
| CAS | 2490589-11-0 |
| Formula | C35H39ClF3N5O3 |
| Molar Mass | 670.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925. |
sEH/AChE-IN-3
CAS: 2490589-11-0 F: C35H39ClF3N5O3 W: 670.16
sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AC
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.