| Bioactivity | RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration[1]. |
| Invitro | RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant[2]. |
| In Vivo | RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg)[1]. Animal Model: |
| Name | RTI-118 |
| CAS | 847554-50-1 |
| Formula | C26H32N4O3 |
| Molar Mass | 448.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Schmoutz CD, et al.Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats.Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. [2]. Bonano JS,et al. Effects of the neuropeptide S receptor antagonist RTI-118 |