| Bioactivity | Ac-Leu-Val-{Lys-Aldehyde} is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-{Lys-Aldehyde} significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1]. |
| Name | Ac-Leu-Val-Lys-Aldehyde |
| CAS | 147600-40-6 |
| Sequence | Ac-Leu-Val-{Lys-Aldehyde} |
| Shortening | Ac-LV-{Lys-Aldehyde} |
| Formula | C19H36N4O4 |
| Molar Mass | 384.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. [2]. Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. |
Ac-Leu-Val-Lys-Aldehyde
CAS: 147600-40-6 F: C19H36N4O4 W: 384.51
Ac-Leu-Val-{Lys-Aldehyde} is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-{Lys-Aldehyde} significantly
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