| Bioactivity | iNOS inhibitor-10 is an iNOS inhibitor (IC50: 65 nM). iNOS inhibitor-10 has antiproliferative effect against triple negative breast cancer cells[1]. |
| Invitro | iNOS inhibitor-10 (1 μM) inhibits iNOS activity by 83%, and is inactive against eNOS[1].iNOS inhibitor-10 (0.001-100 μM, 5 days) reduces cell viability of MDA-MB-231 cells[1].iNOS inhibitor-10 (25 μM, 24 h) prevents migration of MDA-MB-231 cells[1].iNOS inhibitor-10 (measured in liver microsomes) shows a reasonably metabolic stability, with a t1/2 of 38 min CLint of 39.6 mL/min/Kg[1]. Cell Viability Assay[1] Cell Line: |
| Name | iNOS inhibitor-10 |
| Formula | C22H23N3O2S |
| Molar Mass | 393.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carrión MD, et al. New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer. Eur J Med Chem. 2023 Feb 15;248:115112. |