| Bioactivity | Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties[1]. |
| Invitro | Antitumor agent-84 稳定 c-MYC Pu24T，c-MYC Pu22，CKit1，CKit2，KRAS 和 G4 的 DNA 结构[1]。Antitumor agent-84 (1-10000 nM) 抑制肿瘤类器官和癌症激活的成纤维细胞 (CAF)，IC50 值分别为 161 和 2515 nM[1]。 |
| Name | Antitumor agent-84 |
| Formula | C24H31N7 |
| Molar Mass | 417.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bhuma N, et al. The effect of side chain variations on quinazoline-pyrimidine G-quadruplex DNA ligands. Eur J Med Chem. 2023 Feb 15;248:115103. |