| Bioactivity | YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2]. |
| In Vivo | YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续[1]。 Animal Model: |
| Name | YM543 free base |
| CAS | 655237-16-4 |
| Formula | C23H24O6 |
| Molar Mass | 396.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ikegai K, et, al. Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543. Bioorg Med Chem. 2013 Jul 1;21(13):3934-48. [2]. Nakada N. Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2. Pharm Res. 2017 Apr;34(4):874-886. |