| Bioactivity | 11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively[1]. |
| Target | IC50: 0.13 μM (Rat 11β-HSD1), 0.34 μM (Human 11β-HSD1) |
| In Vivo | A single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver[1]. |
| Name | 11β-HSD1-IN-11 |
| CAS | 859721-81-6 |
| Formula | C15H11F3O3S |
| Molar Mass | 328.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. |