| Bioactivity | WIC1 is a potent Wnt inhibitor. WIC1 can be used for the research of cancer[1]. | ||||||||||||
| Invitro | WICl（10 nM、100 nM、10μM、100 μM）降低 BEAS2B 细胞中的 TFC/LEF 荧光素酶报告基因活性[1]。WICl（10 nM、100 nM、10μM、100 μM）显示出较小的毒性[1]。WICl (1μM) 显著降低 ABSC 增殖[1]。WICl 降低 145 个已知下游 Wnt 信号转导靶基因的 mRNA 表达，例如 CCND1、MYC 和 CTNNB1[1]。WICl (1μM) 降低核定位[1]。 | ||||||||||||
| Name | WIC1 | ||||||||||||
| CAS | 943083-58-7 | ||||||||||||
| Formula | C22H23N3O3 | ||||||||||||
| Molar Mass | 377.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brigitte N, et al. Compositions and methods for treating cancer and improving epithelial homeostasis. Patent. WO2021133460A1. |