| Bioactivity | hAChE-IN-1 (Compound 24) is a potent hAChE inhibitor with an IC50 of 1.09 μM. hAChE-IN-1 inhibits tau-oligomerization with an EC50 of 2.71 μM in cellular tau FRET assay[1]. |
| Invitro | hAChE-IN-1 (Compound 24; 1-10 μM; 24 h) 对转染 WT tau 的 SH-SY5Y 细胞具有神经保护作用[1]。 Cell Viability Assay[1] Cell Line: |
| Name | hAChE-IN-1 |
| Formula | C22H24N4O |
| Molar Mass | 360.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Madhav H, et al. Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. Eur J Med Chem. 2023 Jun 5;254:115354. |