VHL Ligand 14_product_DataBase

CAS: 2010986-87-3 F: C25H34N4O4S W: 486.63

VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding a

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM[1].

Invitro

VHL Ligand 14 (5-10 μM) 维持 PROTAC 中 ER 降解剂的稳定性，促进 ER 降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VHL Ligand 14 相关抗体: Western Blot Analysis[1] Cell Line:

CAS

2010986-87-3

Formula

C25H34N4O4S

Molar Mass

486.63

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Hu J, et al., Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). J Med Chem. 2019 Feb 14;62(3):1420-1442.

PeptideDB

VHL Ligand 14

CAS: 2010986-87-3 F: C25H34N4O4S W: 486.63