USP7-IN-7_product_DataBase

Bioactivity	USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].
Invitro	USP7-IN-7 (0-1 μM) 对 p53 野生型血液癌细胞系具有细胞毒性，对 M07e，OCI-AML5，MOLM13 和 MM.IS 的 CC50 值分别为 0.2，0.2，0.4 和 0.1 μM[1]。USP7-IN-7 (0-2 μM) 对 p53 野生型神经母细胞瘤细胞株具有细胞毒性，对 SH-SY5Y，CHP-134 和 NB-1 的 CC50 值分别为 1.9，0.6 和 0.5 μM[1]。USP7-IN-7 (0-25 μM) 对 p53 突变癌细胞系具有细胞毒性，对 H526，LA-N-2 和 SK-N-DZ 的 CC50 值分别为 0.5，0.2 和 0.2 μM[1]。
Name	USP7-IN-7
CAS	2413944-70-2
Formula	C27H28ClN3O3S
Molar Mass	510.05
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.

PeptideDB