Ethaverine hydrochloride

CAS: 985-13-7 F: C24H30ClNO4 W: 431.95

Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride

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Bioactivity	Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].
Invitro	Ethaverine hydrochloride (10 μM，PC12 细胞) 通过阻断 L 型电压敏感 Ca2+ 通道来减少儿茶酚胺分泌[2]。Ethaverine hydrochloride (12 h) 通过抑制 PC12 细胞中的酪氨酸羟化酶 (TH) 活性来降低多巴胺含量，IC50 为 1.4 μM[3]。Ethaverine hydrochloride 抑制小鼠脑中的单胺氧化酶 (MAO) (分离自小鼠全脑) 活性，IC50 为 25.5 μM[6]。
In Vivo	Ethaverine hydrochloride (2-10 mg/kg，静脉滴注，i.v.) 引起豚鼠耳蜗内电位显着升高[4]。Ethaverine (1-10 mg/kg，静脉注射) 抑制麻醉狗的房室传导和心率[5]。 Animal Model:
Name	Ethaverine hydrochloride
CAS	985-13-7
Formula	C24H30ClNO4
Molar Mass	431.95
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. [2]. Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. [3]. Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. [4]. Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. [5]. Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. [6]. Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40.