| Bioactivity | dBRD9 is a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1]. | |||||||||
| Invitro | dBRD9 (0.5-5000 nM；4 h) 在 MOLM-13 细胞中以浓度依赖性方式降低 BRD9 的表达，对肌动蛋白、BRD4、BRD7 表达无显著影响[1]。dBRD9 (100 nM；2 h) 在 MOLM-13 细胞中对 BRD9 具有选择性[1]。dBRD9 (7 d) 对 EOL-1 和 MOML-13 细胞系有抗增殖作用[1]。 Western Blot Analysis[1] Cell Line: | |||||||||
| Name | dBRD9 | |||||||||
| CAS | 2170679-45-3 | |||||||||
| Formula | C40H45N7O10 | |||||||||
| Molar Mass | 783.83 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|
|||||||||
| Reference | [1]. Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. |