Tubulin polymerization-IN-12_product_DataBase

Bioactivity	Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells[1].
Invitro	Tubulin polymerization-IN-12 (compound 6) 对正常人胚胎肾细胞 HEK-293 显示出细胞毒性，IC50 值为 29.94 μM[1]。Tubulin polymerization-IN-12 (compound 26) 抑制癌细胞的 IC50 分别为 1.02 μM (A549)，0.75 μM (HeLa)，10.91 μM (HCT116)，和 29.94 μM (HEK293)[2]。Tubulin polymerization-IN-12 (1 μM, 2 μM, 10 μM; 6 h) 抑制 HeLa 细胞中的微管蛋白表达，在 10 μM 时抑制率为 42%[2]。Tubulin polymerization-IN-12 (0.75 μM-3 μM；24 h) 使 HeLa 细胞的细胞周期停滞在 G2/M 期[2]。 Immunofluorescence[2] Cell Line:
Name	Tubulin polymerization-IN-12
CAS	2377301-45-4
Formula	C23H23N5O6
Molar Mass	465.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yang F, et al. Synthesis, and biological evaluation of 3, 6-diaryl-[1, 2, 4] triazolo [4, 3-a] pyridine analogues as new potent tubulin polymerization inhibitors[J]. European Journal of Medicinal Chemistry, 2020, 204: 112625. [2]. Yang F, et al. Novel [1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities[J]. Bioorganic Chemistry, 2019, 92: 103260.

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