ATX inhibitor 18_product_DataBase

Bioactivity	ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1].
Invitro	ATX inhibitor 18 (compound 8b) (10 µM; 48 h) 在 CFs、t-HSC/Cl-6 细胞中显示出抗增殖活性[1]。TX inhibitor 18 (0-4 µM) 具有抗纤维化活性，对 CF、t-HSC/Cl-6 细胞的 IC50 值分别为 0.87 和 1.10 µM[1]。 Cell Viability Assaysup>[1] Cell Line:
Name	ATX inhibitor 18
CAS	2402772-30-7
Formula	C21H17Cl2FN6O
Molar Mass	459.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiang N, et al. Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis. Eur J Med Chem. 2020 Feb 1;187:111904.

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