| Bioactivity | YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1]. |
| Invitro | YL93 (0.078-2.5 μM; 24 h) 增加 p53、p21、MDM2 的蛋白质水平[1]。YL93 (0.02-2.5 μM; 24 h) 使细胞周期停滞在 G1[1]。YL93 (6.25-25 μM; 48 h) 增加凋亡 RKO 细胞[1]。YL93 (2.5 μM；48 小时) 增加 MDM4 过表达细胞系 H460、MCF-7 和 U-2 OS 中 p53 靶向基因 MDM2、p21 和 PUMA 的转录[1]。 Western Blot Analysis[1] Cell Line: |
| Name | YL93 |
| CAS | 2771313-42-7 |
| Formula | C37H38Cl2F2N4O4 |
| Molar Mass | 711.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang S, et al. Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells. J Med Chem. 2022 Apr 28;65(8):6207-6230. |