| Bioactivity | Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1]. |
| Invitro | Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1]. Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1]. |
| Name | Topotecan hydrochloride hydrate |
| CAS | 1044663-62-8 |
| Formula | C23H26ClN3O6 |
| Molar Mass | 475.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Topotecan hydrochloride hydrate
CAS: 1044663-62-8 F: C23H26ClN3O6 W: 475.92
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrat
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