| Bioactivity | S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities[1][2]. |
| Invitro | S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1]. |
| Name | S65487 sulfate |
| CAS | 2416937-01-2 |
| Formula | C41H43ClN6O8S |
| Molar Mass | 815.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
S65487 sulfate
CAS: 2416937-01-2 F: C41H43ClN6O8S W: 815.33
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 sulfate is also active o
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.