| Bioactivity | Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3]. |
| Invitro | 替加色罗 (3-5 μM; 24-72 小时) 引起显着的时间和剂量依赖性细胞凋亡增加[1]。替加色罗 (3-5 μM; 8-18 小时) 降低 p-S6 ，p-p70 S6 (Thr421/Ser424)[1]。替加色罗 (0.1-3 μM; 24 小时) 有效抑制 5-HT 介导的大鼠离体胃底收缩 (pA2=8.3)，与 5-HT2B 受体拮抗剂活性一致[3]。 Apoptosis Analysis[1] Cell Line: |
| Name | Tegaserod |
| CAS | 145158-71-0 |
| Formula | C16H23N5O |
| Molar Mass | 301.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Tegaserod
CAS: 145158-71-0 F: C16H23N5O W: 301.39
Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod ha
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.