| Bioactivity | Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2]. | ||||||
| Invitro | Thanatin TFA 具有强阳离子性 (pI 为 10.48)，并包含一个独特的短八残基碱性环，该环是通过 C 末端残基 Cys11 和 Cys18 之间形成二硫键而形成的[1]。Thanatin TFA 在 0.4-3.2 μM 的最低抑制浓度 (MIC) 值下对所有 New Delhi metallo-β-lactamase-1 (NDM-1) 产生的大肠杆菌和肺炎克雷伯菌菌株的生长表现出有效的抑制作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Thanatin TFA 相关抗体: | ||||||
| In Vivo | Thanatin (1、3、6mg/kg；腹腔注射；1 小时和 6 小时) TFA 可保护感染 NDM-1 产生的大肠杆菌的小鼠[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| Sequence | Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18) | ||||||
| Shortening | GSKKPVPIIYCNRRTGKCQRM (Disulfide bridge:Cys11-Cys18) | ||||||
| Formula | C103H177N35O27S3.xC2HF3O2 | ||||||
| Molar Mass | 2433.92 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Rachita Dash, et al. Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action. Int J Mol Sci. 2021 Feb 3;22(4):1522. [2]. Bo Ma, et al. The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase. Nat Commun. 2019 Aug 6;10(1):3517. |
Thanatin TFA
CAS: F: C103H177N35O27S3.xC2HF3O2 W: 2433.92 (free base)
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-c
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