PD-L1-IN-4_product_DataBase

Bioactivity	PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer[1].
Invitro	PD-L1-IN-4 (0.1-10 μM，24 h) 可减轻 PD-L1 的免疫抑制作用，并减少 PD-L1/aAPC/CHO-K1 细胞中细胞表面可接近的 PD-L1[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PD-L1-IN-4 相关抗体:
In Vivo	药代动力学分析[1]Route
CAS	2597056-86-3
Formula	C38H40ClFN4O8
Molar Mass	735.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu L, et al. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity. J Med Chem. 2024 Mar 11.

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