| Bioactivity | SRC-3-IN-1(compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor(IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research[1]. |
| Invitro | SRC-3-IN-1(不同浓度， 72 h) 对多种癌细胞系有高效力[1]。SRC-3-IN-1 对非靶标具有高选择性与其个位数纳米分子效力相比[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SRC-3-IN-1 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | SRC-3-IN-1(50， 100 mg/kg， po； 连续 4 周每天服用) 不会导致小鼠体重下降[1]。SRC-3-IN-1(10mg /kg， ip； 每天一次持续 4 周) 通过抑制肿瘤血管生成而延长小鼠存活时间[1]。SRC-3-IN-1(10mg /kg/day， ip； 每天一次持续4周) 使肿瘤面积与股骨面积之比降低 50% 以上[1]。Pharmacokinetic Analysis in CD-1 Mice[1]Route |
| Formula | C14H12F2N6 |
| Molar Mass | 302.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lu D, et al. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy[J]. Journal of Medicinal Chemistry, 2024, 67(7): 5333-5350. |