| Bioactivity | SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1]. |
| Target | IC50: 2.1 μM (SMS1) |
| Invitro | SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM[1]. |
| Name | SMS1-IN-1 |
| CAS | 1807943-38-9 |
| Formula | C23H23BrN2O4S |
| Molar Mass | 503.41 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Li YL, et al. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23(18):6173-84. |
SMS1-IN-1
CAS: 1807943-38-9 F: C23H23BrN2O4S W: 503.41
SMS1-IN-1, compound SAPA 1j,is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value
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