| Bioactivity | BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM. | ||||||||||||
| Target | IC50: 0.023 μM (HSL). | ||||||||||||
| Invitro | BAY 59-9435 significantly diminishes the isoproterenol-increased media IL-6. BAY 59-9435 blocks isoproterenol-induced SphK1 expression[3]. Western Blot Analysis[3] Cell Line: | ||||||||||||
| Name | BAY 59-9435 | ||||||||||||
| CAS | 654059-21-9 | ||||||||||||
| Formula | C14H22N2O3 | ||||||||||||
| Molar Mass | 266.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ebdrup S, et al. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem. 2004 Jan 15;47(2):400-10. [2]. Elizabeth A Rondini, et al. Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown AdipocytesJ Pharmacol Exp Ther. 2017 Dec;363(3):367-376. [3]. Wenliang Zhang, et al. Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem. 2014 Nov 14;289(46):32178-85. |