Dehydroepiandrosterone sulfate_product_DataBase

Bioactivity

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].

Invitro

Dehydroepiandrosterone sulfate (DHEAS) selectively increased the length of neurites containing the dendritic marker MAP-2[1].Dehydroepiandrosterone sulfate (DHEAS) has been reported to increase neuronal excitability (firing rate) when directly applied to septal-preoptic neurons[1].Dehydroepiandrosterone (DHEA) is produced in prodigious quantities by the humanadrenal, principally as the 3-sulfoconjugate DHEA sulfate (DS) during intrauterine life[2].Dehydroepiandrosterone sulfate (DHEAS) is generally nontoxic and lacks adverse side effects even when it is administered chronically[3].

In Vivo

DHEAS chronic administration produces a dose-dependent effect on performance[3]. Animal Model:

Name

Dehydroepiandrosterone sulfate

CAS

651-48-9

Formula

C19H28O5S

Molar Mass

368.49

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. [2]. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. [3]. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70.

PeptideDB

Dehydroepiandrosterone sulfate

CAS: 651-48-9 F: C19H28O5S W: 368.49