| Bioactivity | SHP2-IN-14 (compound 27) is an orally active and potent SHP2 allosteric inhibitor (IC50=7 nM) with anti-tumor activity. SHP2-IN-14 inhibits tumor progression in NCI-H358 tumor bearing mice, exhibits good pharmacokinetic characteristics and safty[1]. |
| Name | SHP2-IN-14 |
| CAS | 2673400-91-2 |
| Formula | C22H20Cl2N8O |
| Molar Mass | 483.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang X, et al. Preparation of heteroaryl derivatives as antitumor agents. World Intellectual Property Organization, WO2021143680 A1 2021-07-22. |
SHP2-IN-14
CAS: 2673400-91-2 F: C22H20Cl2N8O W: 483.35
SHP2-IN-14 (compound 27) is an orally active and potent SHP2 allosteric inhibitor (IC50=7 nM) with anti-tumor activity.
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