| Bioactivity | MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection[1]. |
| Invitro | MKA031 (compound 6y) (1-100 μl;3 h) 阻止 MNNG 诱导的细胞死亡[1]。MKA031 (compound 6y) (100 μl;3 h) 通过阻断 MIF 向 AIF 的募集来保护基因组 DNA[1]。 Cell Viability Assay[1] Cell Line: |
| Name | MKA031 |
| Formula | C21H17N5O2S |
| Molar Mass | 403.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen D, et al. Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos. J Med Chem. 2023 Jul 13;66(13):8767-8781. |