SARS-CoV-2 3CLpro-IN-13_product_DataBase

Bioactivity	SARS-CoV-2 3CLpro-IN-13 is a potent SARS-CoV-2 3CL protease inhibitor with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-13 shows anti-coronavirus activity[1].
Target	IC50: 21 nM (SARS-CoV-2 3CL protease)
Invitro	SARS-CoV-2 3CLpro-IN-13 (compound 1) 显示出抗冠状病毒活性，对于 hCoV-229E (Alpha-CoV) 3CLpro，SARS-CoV-2 (Beta-CoV) 3CLpro、SARS-CoV (Beta-CoV) 3CLpro、MERS-CoV (Beta-CoV) 3CLpro 的 IC50 值分别为 0.016、0.021、0.383、2.00 µM，[1]。SARS-CoV-2 3CLpro-IN-13 (0-300 µM) 对人半胱氨酸蛋白酶具有选择性，对3CLpro SARS-CoV-2，human calpain 1, Cathepsin L 的 IC50 值分别为 1.46、>300、122 µM[1]。SARS-CoV-2 3CLpro-IN-13 (0.1-10 µM) 具有抗病毒活性，对 SARS-CoV-2 和人类冠状病毒 229E 的 IC50 值分别为 1.06、1.34 µM [1]。
Name	SARS-CoV-2 3CLpro-IN-13
CAS	622794-09-6
Formula	C16H16N4S2
Molar Mass	328.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Brier L, et al. Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses. Eur J Med Chem. 2023 Mar 15;250:115186.

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