| Bioactivity | BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1]. |
| Invitro | BD-IN-1 (compound 3; 0-100 µM) 具有抗增殖活性，对 SNB-75、UO-31、CAKI-1 细胞和 DU-145、SW-620、NCI-H460 细胞 的 GI50 值分别为 182、479、708 nM 和 13.2、12.0、10.2 µM[1]。 |
| Name | Bromodomain IN-2 |
| CAS | 2445335-77-1 |
| Formula | C16H17ClN2O |
| Molar Mass | 288.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Warstat R, et al. A novel pan-selective bromodomain inhibitor for epigenetic drug design. Eur J Med Chem. 2023 Mar 5;249:115139. |
Bromodomain IN-2
CAS: 2445335-77-1 F: C16H17ClN2O W: 288.77
BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF
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