SAMT-247_product_DataBase

Bioactivity	SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].
Invitro	SAMT-247 通过共价修饰 Gag 多聚蛋白[2]。SAMT-247 在被 HIV-1IIIB 感染的 CEM-SS 细胞中显示出 EC50 为 0.6 μM 的抗病毒活性。SAMT-247 显示出较低的细胞毒性(TC50 > 100 μM)[2]。
In Vivo	含有 1% SAMT-247 的凝胶配方保护了六只恒河猴中的五只免受 CCR5(R5)-趋向性 SHIV 阴道感染[3]。
Name	SAMT-247
CAS	850715-59-2
Formula	C12H14N2O3S
Molar Mass	266.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204(12):3315-3328. [2]. Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6(12):887-9. [3]. Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25(15):1833-41.

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