RET-IN-23

CAS: 2479961-46-9 F: C28H28FN11 W: 537.59

RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM

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Bioactivity	RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity[1].
Target	IC50: 1.32 nM (RET-WT); 2.50 nM (RET-CCDC6); 6.54 nM (RET-V804L); 1.03 nM (RET-V804M); 1.47 nM (RET-M918T).
In Vivo	RET-IN-23 (5 mg/kg；口服) 在小鼠中显示出抗肿瘤活性[1]。 Animal Model:
Name	RET-IN-23
CAS	2479961-46-9
Formula	C28H28FN11
Molar Mass	537.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. ZhongHui Chen, et al. Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof. WO2020168939A1.