Prochloraz_product_DataBase

Bioactivity

Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].

Target

IC50: 25 μM (Estrogen receptor), 4 μM (Androgen receptor) and 0.3 μM (Aromatase)EC50: 1 μM (Aryl hydrocarbon receptor (AhR))

Invitro

Prochloraz 强烈抑制麦角甾醇生物合成过程中羊毛甾醇微粒体细胞色素 P-450 依赖性 14α-去甲基化，从而导致膜破裂并最终导致细胞死亡[1]。

In Vivo

为了研究 Prochloraz 对发育的影响，怀孕的 Wistar 大鼠围产期服用 30 mg/kg Prochloraz。结果表明，Prochloraz 显着降低妊娠第 21 天男性胎儿的血浆和睾丸激素水平，而睾丸孕激素水平升高。Prochloraz可延长妊娠期[2] 。

Name

Prochloraz

CAS

67747-09-5

Formula

C15H16Cl3N3O2

Molar Mass

376.67

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54(2-3):309-15. [2]. Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29(1):186-92.

PeptideDB

Prochloraz

CAS: 67747-09-5 F: C15H16Cl3N3O2 W: 376.67