| Bioactivity | Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [1][2]. | ||||||||||||
| Invitro | Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2]. Western Blot Analysis[2] Cell Line: | ||||||||||||
| In Vivo | Beclometasone dipropionate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1]. Animal Model: | ||||||||||||
| Name | Beclometasone dipropionate | ||||||||||||
| CAS | 5534-09-8 | ||||||||||||
| Formula | C28H37ClO7 | ||||||||||||
| Molar Mass | 521.04 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75. [2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27. |
Beclometasone dipropionate
CAS: 5534-09-8 F: C28H37ClO7 W: 521.04
Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist
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