PROTAC AR/AR-V7 degrader-1_product_DataBase

Bioactivity	PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].
Invitro	PROTAC AR/AR-V7 degrader-1 (27c) 有效抑制AR信号通路的转录活性。在22RV1细胞中，PROTAC AR/AR-V7 degrader-1 (27c) 的IC50 为 0.9 μM[1]。PROTAC AR/AR-V7 degrader-1 (27c) 在表达AR剪接变异体的晚期前列腺癌中克服耐药性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PROTAC AR/AR-V7 degrader-1 相关抗体:
CAS	2841308-96-9
Formula	C24H19F4N5O2
Molar Mass	485.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.

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