| Bioactivity | PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis. The inhibitory ability of PI3K/Akt/mTOR-IN-5 (IC50=0.21 μM) on HCT-116 cells is approximately 5.3 times that of PAB (IC50=1.11 μM)[1]. |
| Formula | C30H42N2O7 |
| Molar Mass | 542.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qian Xu, et al. "Design, synthesis, and in vivo and in vitro biological screening of pseudolaric acid B derivatives as potential anti-tumor agents." Bioorganic Chemistry (2024): 107670. |