JAK2/FLT3-IN-3_product_DataBase

Bioactivity	JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].
Invitro	JAK2/FLT3-IN-3 (11r) 对多种癌细胞系表现出抗增殖活性，比如， HEL (IC50= 1.1 μM)、MV4-11 (IC50 = 9.43 nM）、RPMI-8226 (IC50 = 0.793 μM)、NCI-H929 (IC50 = 0.743 μM)、Ba/F3-FLT3-ITD-D835Y (IC50 = 0.099 μM) 和 Ba/F3-FLT3-ITD-F691L (IC50 = 0.042 μM) 细胞系具有强效的抗增殖活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> JAK2/FLT3-IN-3 相关抗体:
In Vivo	JAK2/FLT3-IN-3 (11r) 在大鼠体内表现出中等程度的吸收 (Tmax = 5.33小时)，其峰浓度为 38.7 ng/mL，AUC 为522 ng·h/mL，口服生物利用度为 25.2%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	3038183-53-5
Formula	C34H45N9O2
Molar Mass	611.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sicong Xu, et al. 2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 May:134:106442.

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