| Bioactivity | PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1]. |
| Formula | C24H19FN2O3S |
| Molar Mass | 434.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bhuktar, et al. "Targeting next-generation PDE4 inhibitors in search of potential management of rheumatoid arthritis and psoriasis." Bioorganic Chemistry (2024): 107689. |