| Bioactivity | PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1]. |
| Target | IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC) |
| Name | PF-06250112 |
| CAS | 1609465-89-5 |
| Formula | C22H20F2N6O2 |
| Molar Mass | 438.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50. |
PF-06250112
CAS: 1609465-89-5 F: C22H20F2N6O2 W: 438.43
PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory ef
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