| Bioactivity | PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist[1]. |
| Invitro | PD-156707与人ETA 受体的亲和力约为与人ETB受体的亲和力的800倍相比较高[1]。PD-156707抑制了对ET-1的功能反应，包括在表达重组人ETA受体的Ltk细胞中的肌醇磷酸生成（IC50=2.4 nM），以及在兔肾动脉平滑肌细胞中的花生四烯酸释放(IC50=1.1 nM)[1]。 |
| Name | PD-156707 |
| CAS | 162412-70-6 |
| Formula | C28H25NaO9 |
| Molar Mass | 528.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Andrew C. G. Uprichard, et al. PD- 156707: A Selective Endothelin-A Receptor Antagonist. Cardiovascular Drug Reviews Vol. 16, No. 2, pp. 89-104. [2]. D P Ignasiak, et al. Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits. Eur J Pharmacol. 1997 Mar 5;321(3):295-300. |