| Bioactivity | RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1]. |
| In Vivo | RP 67580（0.03-1 mg/kg；静脉注射；单剂量）显著抑制神经源性炎症。 Animal Model: |
| Name | RP 67580 |
| CAS | 135911-02-3 |
| Formula | C29H30N2O2 |
| Molar Mass | 438.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Garret C, et al. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12. |