| Bioactivity | CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1]. |
| Invitro | CPUY201112 (0-9 μM, 7 days) 以剂量依赖的方式降低多种癌细胞系的活力, 如 HCT116 结肠细胞、HepG2 肝细胞癌和其他癌细胞[1]。 CPUY201112 (0-2 μM, 24 h) 可以剂量依赖性诱导细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) 在 MCF-7 肿瘤异种移植模型中抑制了肿瘤生长[1]。 Animal Model: |
| Name | CPUY201112 |
| CAS | 1860793-58-3 |
| Formula | C19H23N3O4 |
| Molar Mass | 357.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiao-Li X, et al. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. Sci Rep. 2016 Jan 8;6:19004. |
CPUY201112
CAS: 1860793-58-3 F: C19H23N3O4 W: 357.40
CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in
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