| Bioactivity | PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia[1]. |
| Target | PCSK9 |
| Name | PCSK9-IN-15 |
| CAS | 2455423-94-4 |
| Formula | C22H28N6O2S2 |
| Molar Mass | 472.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Serrano-Wu MH, et al. Preparation of 2-[[2-methyl-3-[[5-(methylthio)pyrimidin-2-yl]amino]propyl]amino]benzo[d]thiazoles and analogs as PCSK9 inhibitors and methods of their use. World Intellectual Property Organization, WO2020150474 A1. 2020-07-23. |