A1/A3 AR antagonist 3_product_DataBase

Bioactivity	A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases[1].
Target	pKd: 8.25 (A1R); 7.87 (A3R).pKi: 8.36 (A1R); 8.01 (A3R).
Invitro	A1/A3 AR antagonist 3 对 A1R 和 A3R 具有结合亲和力，pKd 值分别为 8.25 和 7.87[1]。A1/A3 AR antagonist 3 对 A1R 和 A3R 具有结合亲和力，pKi 值分别为 8.36 和 8.01[1]。
Name	A1/A3 AR antagonist 3
CAS	2665804-57-7
Formula	C22H19N5O3
Molar Mass	401.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Stampelou M, et al. Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations. J Med Chem. 2022;65(19):13305-13327.

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