P-CAB agent 2_product_DataBase

Bioactivity	P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].
Invitro	P-CAB agent 2 (100 µM) 抑制 hERG 钾通道，抑制率为 86.21%，IC50 值为 18.69 M[1]。
In Vivo	P-CAB agent 2 (example 1) 抑制组胺 (histamine (HY-B1204)) 诱导的 SD 大鼠胃酸分泌[1].P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) 无急性毒性，600mg/kg 对 SD 大鼠动物体重无显着影响[1]。 Animal Model:
Name	P-CAB agent 2
CAS	1978371-23-1
Formula	C22H25FN2O4S
Molar Mass	432.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

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