| Bioactivity | OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (DOX; HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX[1]. | |||||||||
| Invitro | OTS193320 (0.125-0.5 μM; 24 小时) 可以抑制乳腺癌细胞系的增殖。OTS193320 对 SUV39H2 阳性 A549 肺癌细胞具有生长抑制作用 (IC50=0.38 μM)[1]。 OTS193320 (0.5 μM; 48 小时) 诱导乳腺癌细胞凋亡[1]。 OTS193320 (0.125-0.5 μM; 24 小时) 以剂量依赖性方式降低 H3K9me3 水平[1]。 OTS193320 通过减弱 γ-H2AX 使乳腺癌细胞对多柔比星 (Doxorubicin) 敏感。与任一药物的单一药物治疗相比，OTS193320 和多柔比星的组合在体外显着降低癌细胞活力[1]。 Cell Viability Assay[1] Cell Line: | |||||||||
| Name | OTS193320 | |||||||||
| CAS | 2093401-33-1 | |||||||||
| Formula | C28H30ClN5O4 | |||||||||
| Molar Mass | 536.02 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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OTS193320
CAS: 2093401-33-1 F: C28H30ClN5O4 W: 536.02
OTS193320, a imidazopyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global his
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