| Bioactivity | Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2]. |
| Invitro | Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation[1].Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated frommild to moderate asthmatics), and induces sputum eosinophil apoptosis[2].Flunisolide hemihydrate (0.1-10 µM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells[3].Flunisolide hemihydrate (115 µM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent[4]. Apoptosis Analysis[2] Cell Line: |
| Name | Flunisolide hemihydrate |
| CAS | 77326-96-6 |
| Formula | C24H33FO7 |
| Molar Mass | 443.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Flunisolide hemihydrate
CAS: 77326-96-6 F: C24H33FO7 W: 443.51
Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-infla
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