αβ-Tubulin-IN-1_product_DataBase

Bioactivity	αβ-Tubulin-IN-1 is a potent and orally active αβ-Tubulin inhibitor. αβ-Tubulin-IN-1 induces cell cycle arrest at G2/M and efficient apoptosis. αβ-Tubulin-IN-1 inhibits tumor cell migration and Metastasis. αβ-Tubulin-IN-1 shows significant antitumor efficacy in a dose dependent manner[1].
Invitro	αβ-Tubulin-IN-1 (compound 12 b) (0, 0.5, 1, 5, 10, 50 µM; 16 h) promotes αβ-tubulin degradation in a concentration-dependent manner in Hela and K562 (0-10 µM) cells[1].αβ-Tubulin-IN-1 exhibits potent cytotoxic activity toward sensitive cells and resistant cells[1].αβ-Tubulin-IN-1 (0-300 nM; 48 h) induces cell cycle arrest at G2/M and efficient apoptosis in A2780S and A2780T cells[1].αβ-Tubulin-IN-1 (0, 1.25, 2.5, 5, 10 nM; 24, 48 h) inhibits tumor cell migration and Metastasis with the inhibition rate of 76.21% and 85.07% for 24 , 48 h in human umbilical vein endothelial cells (HUVEC)[1]. Cell Proliferation Assay[1] Cell Line:
Name	αβ-Tubulin-IN-1
CAS	2478584-74-4
Formula	C25H19N3O3
Molar Mass	409.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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