| Bioactivity | Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD)[1]. |
| Invitro | Nrf2/HO-1 activator 2 (compound 13m; 0.1-30 µM; 24 h) has protection to PC12 cells against toxicity and inhibits 6-OHDA- and Rotenone (HY-B1756)- induced cell death[1].Nrf2/HO-1 activator 2 (1-100 µM; 11 h) inhibits 6-OHDA- or rotenone-induced production of reactive oxygen species and partially attenuates lipid peroxidation in rat brain homogenates. Nrf2/HO-1 activator 2 inhibits the production of lipid peroxide in rat brain homogenates by 28.8% at 100 μM[1].Nrf2/HO-1 activator 2 (1-100 µM; 11 h) up-regulates heme oxygenase-1 (HO-1) and Nrf2 expression[1].Nrf2/HO-1 activator 2 (10 µM; 2-3 h; PC12 cells) activator 2 activates Nrf2/HO-1 signaling by phosphorylated ERK1/2, JNK, and Akt[1]. Cell Viability Assay[1] Cell Line: |
| Name | Nrf2/HO-1 activator 2 |
| Formula | C20H16F2O5 |
| Molar Mass | 374.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lu Q, et, al. Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling. Eur J Med Chem. 2022 Nov 15;242:114692. |
Nrf2/HO-1 activator 2
CAS: F: C20H16F2O5 W: 374.33
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activa
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